2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158818
    DXR-IN-2
    		Inhibitor
    DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR.
    DXR-IN-2
  • HY-W654156
    Diclazuril-13C3,15N2
    		Inhibitor
    Diclazuril-13C3,15N2 is 13C and 15N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
    Diclazuril-<sup>13</sup>C<sub>3</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-B0244R
    Praziquantel (Standard)
    		Inhibitor
    Praziquantel (Standard) is the analytical standard of Praziquantel. This product is intended for research and analytical applications. Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis.
    Praziquantel (Standard)
  • HY-13735R
    Quinacrine (Standard)
    Quinacrine (Standard) is the analytical standard of Quinacrine. This product is intended for research and analytical applications. Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).
    Quinacrine (Standard)
  • HY-B0147AR
    Pefloxacin mesylate (Standard)
    		Inhibitor
    Pefloxacin mesylate (Standard) (Pefloxacinium mesylate (Standard)) is the analytical standard of Pefloxacin mesylate (HY-B0147A). This product is intended for research and analytical applications. Pefloxacin (Pefloxacinium) mesylate is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin mesylate inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin mesylate exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin mesylate has anti-Plasmodium yoelii infection activity. Pefloxacin mesylate increase UVA-induced edema and immunesuppression. Pefloxacin mesylate can be used for infection studies.
    Pefloxacin mesylate (Standard)
  • HY-170840
    Antimalarial agent 47
    		Inhibitor
    Antimalarial agent 47 (compound F14) is an antimalarial compound, with an IC50 of 235 nM for the Plasmodium falciparum W2 strain.
    Antimalarial agent 47
  • HY-N0924R
    (±)-Stylopine (Standard)
    (±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.
    (±)-Stylopine (Standard)
  • HY-126489
    Tetromycin B
    Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC50=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s=71.77 and 20.2 μM, respectively).
    Tetromycin B
  • HY-125596
    Lachnumon
    		Inhibitor
    Lachnumon is a fungal metabolite with nematicidal and antimicrobial activities.
    Lachnumon
  • HY-145530
    (S)-Hydroxychloroquine sulfate
    		Control
    (S)-Hydroxychloroquine ((S)-HCQ) sulfate is an isomer of Hydroxychloroquine (HY-W031727). (S)-Hydroxychloroquine sulfate (2.5-20 mg/mL) reduces the rate of insulin degradation in liver homogenates isolated from non-diabetic and diabetic rats. Formulations containing Hydroxychloroquine have been used in the study of malaria, rheumatoid arthritis, and systemic lupus erythematosus.
    (S)-Hydroxychloroquine sulfate
  • HY-149697
    Insecticidal agent 6
    		Inhibitor
    Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC50 value of 0.6308 µM against S. frugiperda RyRs. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases.
    Insecticidal agent 6
  • HY-B1322BR
    Amodiaquine dihydrochloride (Standard)
    		Inhibitor
    Amodiaquine (dihydrochloride) (Standard) is the analytical standard of Amodiaquine (dihydrochloride). This product is intended for research and analytical applications. Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
    Amodiaquine dihydrochloride (Standard)
  • HY-170219
    3-Methyl-4-(3-methyl-4-oxo-2,4,5,6,7,8-hexahydrocyclohepta[c]pyrrol-1-yl)benzamide
    		Inhibitor
    RMM23 is an inhibitor targeting PfBDP1 with a Kd value of 1.24 μM. RMM23 against the wild-type strains 3D7 and NF54, and the multidrug-resistant K1 strain in vitro blood stage, with EC50 values of 18 μM, 14 μM, 20 μM, respectively .
    3-Methyl-4-(3-methyl-4-oxo-2,4,5,6,7,8-hexahydrocyclohepta[c]pyrrol-1-yl)benzamide
  • HY-B1120R
    Temephos (Standard)
    		Inhibitor
    Temephos (Standard) is the analytical standard of Temephos. This product is intended for research and analytical applications. 0
    Temephos (Standard)
  • HY-12639AR
    Bephenium (hydroxynaphthoate) (Standard)
    		Inhibitor
    Bephenium (hydroxynaphthoate) (Standard) is the analytical standard of Bephenium (hydroxynaphthoate). This product is intended for research and analytical applications.
    Bephenium (hydroxynaphthoate) (Standard)
  • HY-112905
    AN11736
    		Inhibitor
    AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC50s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models.
    AN11736
  • HY-N13881
    Amythiamicin C
    		Inhibitor
    Amythiamicin C is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum.
    Amythiamicin C
  • HY-173028
    RH01201
    		Inhibitor
    RH01201 is the non-competitive inhibitor for plasmepsin II with a Ki of 123 μM.
    RH01201
  • HY-13685R
    Miltefosine (Standard)
    Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT).
    Miltefosine (Standard)
  • HY-117241
    AB 3217-B
    		Inhibitor
    AB 3217-B is an analog of AB 3217-A and has anti-mite activity.
    AB 3217-B
Parasite Isoform Comparison

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